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The regulation of Schwann cell growth in vitro is facilitated by heregulin, a neuron-secreted growth factor, and an unknown mitogen that activates the cyclic adenosine monophosphate (cAMP) pathway. The quantity of cAMP available to Schwann cells can determine if they become a myelinating or proliferating phenotype. The abundance of intracellular cAMP available to the cell is widely regulated by a family of enzymes called phosphodiesterases (PDEs). PDE inhibitors such as rolipram have therapeutic potential in various disorders and function by increasing the levels of cAMP in the cell. This study was undertaken to determine the concentration of rolipram that would induce optimal Schwann cell proliferation. It was hypothesized that an increase in rolipram levels will elicit a dose-dependent rise in cell proliferation.
Schwann cells, Rolipram, Cell proliferation, Cell Biology, Cancer cells
Cancer Biology | Cell Biology | Molecular Biology
Kenney, Kyle; Bohn, Amanda; and Asirvatham, Angela, "The Effects of Rolipram, a Selective Phosphodiesterase Inhibitor, on Immortalized Schwann Cell Proliferation" (2020). Student Research Poster Presentations 2020. 57.