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Home > STUDENTSYMPOSIA > SURF > SURF2023

SURF Posters 2023

 

The Misericordia University Summer Undergraduate Research Fellowship Program (SURF) is sponsored by the Vice President of Academic Affairs Office.

Research fellows receive one-on-one, faculty-guided research opportunities and participate in bi-weekly professional development seminars geared toward preparing them for graduate school, future research experiences, and employment.

The summer program culminates with two presentations of the students’ findings: a 10-minute oral presentation in the last week of the program and a poster presentation in October for the entire campus community, COVID-permitting.

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  • The Effect of LPS on Phosphorylation of AKT Signaling in Schwann Cells by Nicholas Wilde and Angela Asirvatham

    The Effect of LPS on Phosphorylation of AKT Signaling in Schwann Cells

    Nicholas Wilde and Angela Asirvatham

    Schwann cells (SCs) are cells in the peripheral nervous system that may play a significant role in neuronal repair after an injury, however, little is known about their mechanisms on how they do so. In the lab, lipopolysaccharide (LPS), a bacterial endotoxin, is used to stimulate an injury while forskolin, a growth hormone, is used to activate the cAMP pathway. In this experiment, the cAMP pathway, which is involved in many cellular processes, and protein kinase b (AKT), a cell survival signal, where analyzed in different LPS doses (0.1, 1, and 10 µg/mL) and over different time periods (3-,6-,12-, and 24-hours). It was predicted that cells treated with LPS will increase the expression of activated phospho-AKT as dose and time increases, while cells treated with both LPS and forskolin would have a synergistic effect on the upregulation of phospho-AKT. It was discovered that, in LPS alone, from 1 µg/mL to 10 µg/mL had an increased expression in phospho-AKT across all time intervals besides 24 hours. In LPS and forskolin treatments, a synergistic effect was observed from 1 µg/mL to 10 µg/mL across all time intervals.

 
 
 

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